Description

2-Fluorobenzyl Isocyanate is a versatile and highly reactive aromatic isocyanate building block used in advanced organic synthesis. Its value lies in its ability to introduce the 2-fluorobenzyl moiety into target molecules, enabling the fine-tuning of physical, chemical, and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances bioactivity and environmental stability.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for producing specialized polyurethanes, polyureas, and coatings with tailored properties like chemical resistance or adhesion.
• Chemical Research & Development: A critical reagent in medicinal chemistry for structure-activity relationship (SAR) studies and in the discovery of new chemical entities.
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized ligands for catalysis or as a precursor for metal-organic frameworks (MOFs) and other functional materials.

Basic Information

Product Name	2-Fluorobenzyl Isocyanate
CAS No.	132740-44-4
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	1-Isocyanatomethyl-2-fluorobenzene; (2-Fluorophenyl)methyl isocyanate; 2-Fluorobenzylcarbylamine; o-Fluorobenzyl isocyanate; α-Isocyanato-2-fluorotoluene; 2-Fluorobenzyl isocyanat; 2-Fluoro-benzylisocyanat
EINECS	Contact for details

Quality Control

Our 2-Fluorobenzyl Isocyanate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR). A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.