Description

Glufosfamide is a novel alkylating agent and a glucose-conjugated derivative of isophosphoramide mustard, designed for targeted cancer therapy. This compound is significant for its potential to selectively deliver cytotoxic effects to tumor cells with high glucose metabolism, offering a promising approach in oncology research and development. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) focused on developing advanced chemotherapeutic agents and targeted drug delivery systems.

Application

• Oncological Research: As a key active pharmaceutical ingredient (API) in preclinical and clinical studies for various solid tumors.
• Targeted Chemotherapy Development: Utilized in the formulation of novel conjugates designed to exploit the Warburg effect in cancer cells.
• Mechanistic Studies: Serves as a reference standard in biochemical assays to study DNA alkylation and apoptosis pathways.
• Pharmaceutical Synthesis: An intermediate in the synthesis of more complex targeted anti-cancer prodrugs.
• Comparative Efficacy Testing: Used in in vitro and in vivo models to evaluate potency and selectivity against traditional alkylating agents.

Basic Information

Product Name	Glufosfamide
CAS No.	132682-98-5
Molecular Formula	C12H26Cl2N3O7P
Molecular Weight	426.22 g/mol
Synonyms	D-19575; Glufosfamide; β-D-Glucosylisophosphoramide mustard; (2R,3R,4S,5S,6R)-2-[[bis(2-chloroethyl)aminophosphoryl]amino]-6-(hydroxymethyl)oxane-3,4,5-triol; Glucose-isophosphoramide mustard conjugate; D 19575
EINECS	Contact for details

Quality Control

Our Glufosfamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and stringent control of impurities and residual solvents. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.