Description

(4S)-1-Boc-4-Azido-D-Proline Ethyl Ester is a high-purity, non-natural amino acid derivative featuring a protected amine and a reactive azido group. This compound is a critical chiral building block for the synthesis of complex molecules, enabling the introduction of proline-like scaffolds with orthogonal functionality for further conjugation. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, medicinal chemistry, and the development of novel bioconjugates and drug candidates.

Application

• Peptide Synthesis: Serves as a key intermediate for incorporating modified proline residues into peptide chains, influencing secondary structure and biological activity.
• Medicinal Chemistry & Drug Discovery: Used as a versatile scaffold for constructing peptidomimetics and probing structure-activity relationships (SAR) in lead optimization.
• Click Chemistry: The azido functional group enables efficient, site-specific conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkynes.
• Bioconjugation: Facilitates the labeling and modification of biomolecules (proteins, antibodies, oligonucleotides) for diagnostic and therapeutic applications.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and tools for studying enzyme function and biological pathways.
• Combinatorial Chemistry: A valuable building block for generating diverse chemical libraries for high-throughput screening.

Basic Information

Product Name	(4S)-1-Boc-4-Azido-D-Proline Ethyl Ester
CAS No.	132623-06-4
Molecular Formula	C₁₂H₂₀N₄O₄
Molecular Weight	284.31 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-azido-D-proline ethyl ester; Ethyl (4S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-azidopyrrolidine-2-carboxylate; D-Proline, 1-[(1,1-dimethylethoxy)carbonyl]-4-azido-, ethyl ester, (4S)-; 4-Azido-1-Boc-D-proline ethyl ester; Boc-4-Azido-D-Pro-OEt; Azido-D-proline derivative; tert-Butyl (4S)-4-azido-2-(ethoxycarbonyl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (4S)-1-Boc-4-Azido-D-Proline Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and optical rotation measurement, to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place, away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.