Description

(4R)-1-Boc-4-Azido-L-Proline Ethyl Ester is a high-purity, chiral proline derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its dual functionality, incorporating both a Boc-protected amine and an azide group, enabling its use in click chemistry and peptide coupling strategies. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptidomimetics, and bioconjugates.

Application

• Peptide Synthesis: A key chiral intermediate for introducing constrained proline analogs into peptide chains to modulate biological activity and stability.
• Click Chemistry: The azide moiety enables efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and material science applications.
• Pharmaceutical Research: Used in the discovery and development of protease inhibitors, receptor agonists/antagonists, and other bioactive molecules.
• Combinatorial Chemistry: Serves as a versatile scaffold for generating diverse chemical libraries in drug discovery programs.
• Bioconjugation Probes: Facilitates the site-specific labeling of proteins, antibodies, or other biomolecules for diagnostic and therapeutic purposes.
• Academic Research: Employed in methodological studies exploring new synthetic routes and asymmetric catalysis.

Basic Information

Product Name	(4R)-1-Boc-4-Azido-L-Proline Ethyl Ester
CAS No.	132623-04-2
Molecular Formula	C₁₂H₂₀N₄O₄
Molecular Weight	284.31 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-azido-L-proline ethyl ester; (4R)-1-[(1,1-Dimethylethoxy)carbonyl]-4-azido-2-pyrrolidinecarboxylic acid ethyl ester; Ethyl (4R)-1-Boc-4-azidoproline; Ethyl (4R)-4-azido-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylate; 4-Azido-L-proline, 1-Boc-, ethyl ester; Boc-4-Azido-L-Pro-OEt; Azido-Pro(Boc)-OEt; L-Proline, 4-azido-1-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester, (4R)-
EINECS	Contact for details

Quality Control

Our (4R)-1-Boc-4-Azido-L-Proline Ethyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, well-ventilated area. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere to prevent degradation. For long-term storage, consider storing under nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.