Description

(4R)-1-Boc-4-Azido-D-Proline Benzyl Ester is a high-purity, non-natural amino acid derivative designed for advanced synthetic applications. This compound is a critical chiral building block, valued for its reactive azido group and protected amine functionality, enabling precise chemical modifications. It is primarily needed by researchers and process chemists in the pharmaceutical and biotechnology industries for the synthesis of complex peptides, peptidomimetics, and novel drug candidates.

Application

• Peptide Synthesis: A key chiral intermediate for constructing conformationally constrained peptides and peptidomimetics.
• Click Chemistry: The azido group facilitates efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and material labeling.
• Pharmaceutical Research: Used in the development of protease inhibitors, receptor agonists/antagonists, and other bioactive molecules.
• Chemical Biology Probes: Enables the synthesis of activity-based probes for studying enzyme function and protein-protein interactions.
• Library Synthesis: Serves as a versatile scaffold for generating diverse compound libraries in medicinal chemistry.
• Glycopeptide & Glycomimetic Synthesis: Useful for introducing amino acid motifs into carbohydrate-based drug candidates.

Basic Information

Product Name	(4R)-1-Boc-4-Azido-D-Proline Benzyl Ester
CAS No.	132622-97-0
Molecular Formula	C₁₇H₂₂N₄O₄
Molecular Weight	346.38 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-azido-D-proline benzyl ester; (R)-1-Boc-4-azidoproline benzyl ester; D-4-Azidoproline, 1-Boc-, benzyl ester; Benzyl (4R)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-azidopyrrolidine-2-carboxylate; 4-Azido-D-proline, N-Boc-, benzyl ester; Azido-D-proline benzyl ester Boc derivative; Boc-4-Azido-D-Pro-OBzl
EINECS	Contact for details

Quality Control

Our (4R)-1-Boc-4-Azido-D-Proline Benzyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency for research and development. We prioritize high chiral purity and low impurity profiles, with comprehensive characterization via NMR, HPLC, and MS. Certificates of Analysis (COA) detailing purity, chiral excess, and identity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, well-ventilated area. This compound is moisture-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.