Description

Fmoc-Gln(Trt)-Opfp is a protected amino acid derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the efficient and selective incorporation of glutamine into complex peptide sequences while preventing unwanted side reactions. This high-purity reagent is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester (Opfp), it is a crucial reagent for the efficient, racemization-free coupling of Fmoc-Glutamine in automated and manual peptide synthesis.
• Therapeutic Peptide Production: Used in the research, development, and GMP manufacturing of peptide-based pharmaceuticals, including hormones, antibiotics, and metabolic regulators.
• Combinatorial Chemistry Libraries: Serves as a building block for creating diverse peptide libraries used in high-throughput screening for drug discovery.
• Bioconjugation and Labeling: The reactive pentafluorophenyl ester group allows for selective conjugation of peptides to other molecules, such as fluorescent dyes, polymers, or carrier proteins.
• Academic and Industrial Research: A fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Custom Peptide Service Providers: A core raw material for CROs and CDMOs offering bespoke peptide synthesis services to the global life science community.

Basic Information

Product Name	Fmoc-Gln(Trt)-Opfp
CAS No.	132388-65-9
Molecular Formula	C45H35F5N2O5
Molecular Weight	778.77 g/mol
Synonyms	Fmoc-Gln(Trt)-OPfp; N-α-Fmoc-N-γ-trityl-L-glutamine pentafluorophenyl ester; Fmoc-L-glutamine(trityl)-OPfp ester; Fmoc-Glutamine(Trt)-OPfp; (9H-Fluoren-9-ylmethoxy)carbonyl-γ-trityl-L-glutamine pentafluorophenyl ester; Fmoc-Gln(Trt)-O-Pfp; Pentafluorophenyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-trityl-L-glutaminate
EINECS	Contact for details

Quality Control

Our Fmoc-Gln(Trt)-Opfp is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive peptide synthesis applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.