Description

Des (2-Methylbutyrate) Lovastatin Hydroxy Acid Sodium Salt is a key pharmaceutical intermediate derived from the statin family, specifically a sodium salt derivative of the active hydroxy acid form of lovastatin. This compound is valued for its high purity and defined chemical structure, which are critical for ensuring the efficacy and safety of downstream active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical industry for the development and production of cholesterol-lowering medications and related therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthetic pathway for manufacturing statin-based Active Pharmaceutical Ingredients (APIs) used to treat hypercholesterolemia.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for method development, validation, and impurity profiling of lovastatin and its derivatives.
• Biochemical Research: Used in academic and industrial research to study the mechanism of action of HMG-CoA reductase inhibitors and their metabolic pathways.
• Process Development: Employed in scaling up and optimizing manufacturing processes for next-generation statin drugs to improve yield and purity.
• Formulation Studies: Utilized in pre-formulation research to investigate the stability and compatibility of the hydroxy acid form in various drug delivery systems.

Basic Information

Product Name	Des (2-Methylbutyrate) Lovastatin Hydroxy Acid Sodium Salt
CAS No.	132294-94-1
Molecular Formula	C26H37NaO7
Molecular Weight	484.56 g/mol
Synonyms	Lovastatin Hydroxy Acid Sodium Salt; Monacolin J Sodium Salt; (4R,6R)-6-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one Sodium Salt; Sodium (E)-(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate; Mevinolinic Acid Sodium Salt; 6α-Methylcompactin Sodium Salt; L-154,819 Sodium Salt
EINECS	Contact for details

Quality Control

Our Des (2-Methylbutyrate) Lovastatin Hydroxy Acid Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to ensure it meets stringent specifications suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and related substances are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.