Description

N,o-Bis(Trimethylsilyl)Acetamide is a highly reactive organosilicon reagent primarily used as a powerful silylating agent. This compound is critical for introducing the trimethylsilyl (TMS) protecting group onto sensitive functional groups like hydroxyls and amines, thereby enabling complex synthetic transformations. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for process development and active ingredient synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for protecting hydroxyl and amino groups during the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the manufacture of pesticides and herbicides where sensitive intermediates require protection from reactive conditions.
• Derivatization for Analysis: Employed in Gas Chromatography (GC) and Mass Spectrometry (MS) to silylate polar compounds for improved volatility and detection.
• Polymer & Material Science: Acts as a precursor or modifying agent in the synthesis of specialty silicones and silicon-based polymers.
• Peptide Chemistry: Protects amino acids and peptide fragments during solid-phase and solution-phase peptide synthesis.
• Nucleoside & Carbohydrate Chemistry: Facilitates the selective protection of sugar hydroxyl groups in the synthesis of nucleosides and complex carbohydrates.

Basic Information

Product Name	N,o-Bis(Trimethylsilyl)Acetamide
CAS No.	132255-83-5
Molecular Formula	C8H21NOSi2
Molecular Weight	203.43 g/mol
Synonyms	BSA; N,O-Bis(trimethylsilyl)acetamide; Acetamide, N,N-bis(trimethylsilyl)-; Bistrimethylsilylacetamide; N,O-Bis(trimethylsilyl)acetamide; N-TMS-O-TMS-acetamide; 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine, N-acetyl derivative
EINECS	Contact for details

Quality Control

Our N,o-Bis(Trimethylsilyl)Acetamide is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the stringent requirements of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Chloride (Cl)	≤ 0.01%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.