Description

(S)-1-Benzyl 5-Methyl 2-((tert-Butoxycarbonyl)Amino)Pentanedioate CAS NO 132245-78-4 is a high-purity, chiral amino acid derivative featuring both benzyl ester and tert-butoxycarbonyl (Boc) protecting groups. This compound is critical for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control and orthogonal deprotection strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and bioactive peptide conjugates.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce protected glutamic acid analogs with defined stereochemistry.
• Protease Inhibitor Development: Serves as a precursor in the creation of selective inhibitors for various proteolytic enzymes.
• Bioconjugation & Linker Chemistry: The reactive ester and protected amine functionalities enable its use in constructing drug-linker systems for antibody-drug conjugates (ADCs).
• Chemical Biology Research: Employed in the study of protein-protein interactions and the design of peptide-based probes and tools.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	(S)-1-Benzyl 5-Methyl 2-((tert-Butoxycarbonyl)Amino)Pentanedioate
CAS No.	132245-78-4
Molecular Formula	C19H27NO6
Molecular Weight	365.42 g/mol
Synonyms	Boc-Glu(OBzl)-OMe; (S)-1-Benzyl 5-Methyl 2-((tert-Butoxycarbonyl)Amino)Pentanedioate; N-Boc-L-glutamic acid 1-benzyl 5-methyl ester; Nα-Boc-L-glutamic acid α-benzyl γ-methyl ester; Boc-L-Glu(OBzl)-OMe; N-(tert-Butoxycarbonyl)-L-glutamic acid 1-benzyl 5-methyl ester; L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-(phenylmethyl) 5-methyl ester
EINECS	Contact for details

Quality Control

Our (S)-1-Benzyl 5-Methyl 2-((tert-Butoxycarbonyl)Amino)Pentanedioate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee consistent quality and traceability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.