Description

5'-Isocyano-2',5'-Dideoxyuridine is a specialized nucleoside derivative featuring an isocyano functional group at the 5'-position. This compound serves as a critical synthetic intermediate in the development of novel antiviral and anticancer agents, particularly in the field of nucleoside chemistry and prodrug design. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the synthesis of modified nucleosides and nucleotides.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Prodrug Development: Used in research to create prodrugs designed for targeted drug delivery and improved bioavailability.
• Chemical Biology Research: Serves as a versatile precursor for labeling and modifying nucleic acids in biochemical studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new therapeutic candidates.
• Fine Chemical Synthesis: Acts as a specialized reagent for introducing the isocyano moiety into complex molecular architectures.

Basic Information

Product Name	5'-Isocyano-2',5'-Dideoxyuridine
CAS No.	132125-31-6
Molecular Formula	C10H11N3O5
Molecular Weight	253.21 g/mol
Synonyms	5'-Isocyanato-2',5'-dideoxyuridine; 2',5'-Dideoxy-5'-isocyanouridine; 1-[(2R,5S)-5-Isocyano-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; Uridine, 2',5'-dideoxy-5'-isocyano-; 5'-Isocyano-5'-deoxyuridine derivative; Isocyano nucleoside intermediate
EINECS	Contact for details

Quality Control

Our 5'-Isocyano-2',5'-Dideoxyuridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.