Description

5'-Isocyano-5'-Deoxythymidine is a specialized nucleoside derivative, a key synthetic intermediate for the development of novel pharmaceuticals and bioactive compounds. Its isocyano functional group provides a versatile handle for click chemistry and other advanced coupling reactions, enabling the creation of targeted molecular libraries. This high-purity building block is essential for researchers and manufacturers in pharmaceutical R&D, particularly for the synthesis of antiviral agents, nucleotide analogs, and prodrugs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleotide analogs.
• Prodrug Development: Used in the design and synthesis of targeted prodrugs to enhance drug delivery and efficacy.
• Bio-conjugation Chemistry: The reactive isocyano group enables efficient conjugation to peptides, proteins, and other biomolecules for diagnostic and therapeutic applications.
• Medicinal Chemistry Research: Serves as a versatile scaffold in combinatorial chemistry and high-throughput screening for drug discovery programs.
• Chemical Biology Probes: Utilized in the creation of activity-based probes to study enzyme function and biological pathways.
• Nucleic Acid Chemistry: Intermediate for the modification of oligonucleotides and the development of novel antisense or siRNA therapeutics.

Basic Information

Product Name	5'-Isocyano-5'-Deoxythymidine
CAS No.	132101-22-5
Molecular Formula	C11H13N3O5
Molecular Weight	267.24 g/mol
Synonyms	5'-Isocyano-5'-deoxythymidine; 5'-Deoxy-5'-isocyanothymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 5'-isocyanide; Thymidine 5'-isocyanide; 5'-Isocyanothymidine; 5'-Isocyano-2'-deoxythymidine
EINECS	Contact for details

Quality Control

Our 5'-Isocyano-5'-Deoxythymidine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.