Description

Methoxypolyethylene Glycol 5,000 Trimethylsilyl Ether is a high-purity, monofunctional polyethylene glycol derivative where the terminal hydroxyl group is protected as a trimethylsilyl ether. This chemical modification is critical for applications requiring a non-reactive, hydrophobic end-group to control polymer functionality and reactivity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for polymer conjugation, surface modification, and as a key intermediate in controlled synthesis.

Application

• Pharmaceutical Intermediate: Used in the synthesis of prodrugs and for the modification of active pharmaceutical ingredients (APIs) to alter solubility and pharmacokinetic profiles.
• Polymer Conjugation & Functionalization: Serves as a protected intermediate for creating heterobifunctional PEG linkers used in bioconjugation (e.g., PEGylation of proteins, peptides, and oligonucleotides).
• Surface Modification Agent: Employed to create hydrophilic, protein-resistant coatings on medical devices, sensors, and nanomaterials.
• Hydrophobic End-Capping Reagent: Provides a stable, inert terminus in block copolymer synthesis for applications in drug delivery systems and hydrogels.
• Research & Development: A valuable tool in organic and polymer chemistry R&D for studying polymer behavior and developing new macromolecular architectures.
• Lubricant & Additive Precursor: Acts as a starting material for synthesizing specialized silicone-PEG hybrid lubricants and surface-active agents.

Basic Information

Product Name	Methoxypolyethylene Glycol 5,000 Trimethylsilyl Ether
CAS No.	132068-85-0
Molecular Formula	CnH2n+1O(C2H4O)mSi(CH3)3 (where m ~113 for MW 5000)
Molecular Weight	~5,000 g/mol (nominal)
Synonyms	mPEG5k-TMS; mPEG5000 Trimethylsilyl Ether; Poly(ethylene glycol) methyl ether trimethylsilyl terminated; α-Methoxy-ω-(trimethylsilyloxy)poly(oxyethylene); PEG Methyl Ether TMS; TMS-mPEG5000; Monomethoxy Polyethylene Glycol Trimethylsilyl Ether (MW 5000); O-Methyl-O'-(trimethylsilyl)polyethylene glycol 5000
EINECS	Contact for details

Quality Control

Our Methoxypolyethylene Glycol 5,000 Trimethylsilyl Ether is manufactured under a quality management system. Each batch undergoes rigorous analytical testing to ensure consistent molecular weight distribution, high purity, and functional group integrity. Certificates of Analysis (COA) detailing specifications such as NMR assay, polydispersity index (PDI), and residual moisture are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage under optimal conditions, consider storing under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (NMR)	≥ 95.0%
Average Molecular Weight (GPC/SEC)	5,000 ± 500 g/mol
Polydispersity Index (PDI)	≤ 1.10
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.