Description

3-(4-Azido-5-Iodosalicylamido)-4-Hydroxycoumarin is a specialized heterocyclic organic compound that serves as a critical intermediate in advanced chemical synthesis and life science research. Its unique molecular architecture, featuring an azido group and an iodo-substituted salicylamide moiety fused to a hydroxycoumarin core, makes it a valuable building block for developing novel probes and active pharmaceutical ingredients. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry and biochemical tool development. Its precise structure enables targeted modifications for creating molecules with specific biological activities or photophysical properties.

Application

• Medicinal Chemistry Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting enzymes or receptors where the coumarin scaffold is pharmacologically relevant.
• Photoaffinity Labeling Probe Development: The azido group allows this compound to be used in the creation of photoaffinity labels for studying protein-ligand interactions and mapping binding sites.
• Fluorescent Probe Synthesis: Acts as a starting material for synthesizing advanced fluorescent dyes and sensors, leveraging the inherent photophysical properties of the coumarin core.
• Bioconjugation and Linker Chemistry: Utilized in constructing complex bioconjugates or antibody-drug conjugates (ADCs) where its functional groups enable specific coupling reactions.
• Chemical Biology Research: Employed as a tool compound in research to investigate biological pathways or to develop activity-based probes for diagnostic applications.
• Organic Synthesis Building Block: Used by synthetic chemists to construct more complex heterocyclic systems or libraries for high-throughput screening.

Basic Information

Item	Detail
Product Name	3-(4-Azido-5-Iodosalicylamido)-4-Hydroxycoumarin
CAS No.	132031-99-3
Molecular Formula	C₁₆H₈IN₅O₄
Molecular Weight	461.16 g/mol
Synonyms	4-Hydroxy-3-[(4-azido-5-iodo-2-hydroxybenzoyl)amino]-2H-chromen-2-one; 3-[(4-Azido-5-iodo-2-hydroxybenzoyl)amino]-4-hydroxy-2H-chromen-2-one; 3-(4-Azido-5-iodosalicylamido)-4-hydroxycoumarin; AIH-Coumarin; Azido-iodo-salicylamido coumarin; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Azido-5-Iodosalicylamido)-4-Hydroxycoumarin is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with precise customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.