Description

n-Succinimidyl 8-((4'-Fluorobenzyl)Amino)Suberate is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a fluorobenzyl amine group. This compound is critical for creating stable amide bonds between biomolecules, enabling precise conjugation in complex chemical synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and diagnostic reagent development sectors for antibody-drug conjugate (ADC) development, protein labeling, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: For site-specific labeling of amines on proteins, enzymes, or peptides with fluorophores, tags, or other functional molecules.
• Biomaterial Surface Functionalization: Used to introduce reactive groups onto nanoparticles, microspheres, or biosensor surfaces for subsequent biomolecule immobilization.
• Diagnostic Reagent Synthesis: Employed in the development of immunoassay components, such as enzyme-antibody conjugates.
• Solid-Phase Synthesis: Serves as a building block or activating agent in the synthesis of complex peptides or peptidomimetics.
• Chemical Biology Probes: Facilitates the creation of activity-based probes for studying enzyme function or protein-protein interactions.

Basic Information

Item	Details
Product Name	n-Succinimidyl 8-((4'-Fluorobenzyl)Amino)Suberate
CAS No.	131865-53-7
Molecular Formula	C23H30FN3O6
Molecular Weight	463.50 g/mol
Synonyms	8-[(4-Fluorobenzyl)amino]-N-(2,5-dioxo-1-pyrrolidinyl)octanamide; Suberic Acid N-Succinimidyl Ester 8-((4-Fluorobenzyl)Amino); NHS-Fluorobenzyl-Amino-Suberate; N-Succinimidyl 8-[(4-fluorophenyl)methyl]aminooctanoate; 131865-53-7; Fluorobenzylamino Suberate NHS Ester; Heterobifunctional Crosslinker with NHS and Fluorobenzyl Amine
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 8-((4'-Fluorobenzyl)Amino)Suberate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.