Description

Methyl (3R)-3-Amino-3-(4-Methoxyphenyl)Propanoate CAS NO 131791-82-7 is a high-purity chiral intermediate featuring a β-amino acid ester structure with a methoxyphenyl substituent. This compound is critical for ensuring the stereochemical integrity and efficacy of advanced pharmaceutical agents. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Key Chiral Building Block for the synthesis of enantiomerically pure pharmaceuticals, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Intermediate in Peptidomimetics research, used to incorporate constrained β-amino acid motifs into novel therapeutic peptides.
• Precursor for Asymmetric Catalysis Ligands, serving as a starting material for chiral auxiliaries and catalysts.
• Process Chemistry Development for scaling up the production of optically active intermediates under GMP-like conditions.
• Academic & Industrial R&D in medicinal chemistry for exploring new structure-activity relationships (SAR).

Basic Information

Product Name	Methyl (3R)-3-Amino-3-(4-Methoxyphenyl)Propanoate
CAS No.	131791-82-7
Molecular Formula	C11H15NO3
Molecular Weight	209.24 g/mol
Synonyms	(R)-Methyl 3-amino-3-(4-methoxyphenyl)propanoate; Methyl (R)-3-amino-3-(4-methoxyphenyl)propionate; (3R)-3-Amino-3-(4-methoxyphenyl)propanoic acid methyl ester; β-Amino-4-methoxybenzenepropanoic acid methyl ester, (R)-; (R)-3-Amino-3-(4-methoxyphenyl)propionic acid methyl ester; (R)-3-Amino-3-(p-methoxyphenyl)propionic acid methyl ester; Methyl (R)-3-amino-3-(p-methoxyphenyl)propanoate
EINECS	Contact for details

Quality Control

Our Methyl (3R)-3-Amino-3-(4-Methoxyphenyl)Propanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive analytical data, including Chiral HPLC for enantiomeric excess (ee) verification and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Maximum Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.