Description

Pyridine-3-Boronic Acid 1,3-Propanediol Cyclic Ester is a high-purity, protected boronic acid derivative, specifically the cyclic ester of 3-pyridineboronic acid with 1,3-propanediol. This compound is a critical building block in modern synthetic chemistry, offering enhanced stability and handling characteristics compared to its free boronic acid counterpart. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules via cross-coupling reactions.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, essential for constructing biaryl and heterobiaryl structures found in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and production of drug candidates, particularly those containing pyridine or substituted pyridine moieties.
• Agrochemical Development: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Employed in the synthesis of organic ligands for catalysts, metal-organic frameworks (MOFs), and advanced polymeric materials.
• Chemical Library Production: A valuable scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	Pyridine-3-Boronic Acid 1,3-Propanediol Cyclic Ester
CAS No.	131534-65-1
Molecular Formula	C9H12BNO3
Molecular Weight	193.01 g/mol
Synonyms	3-Pyridineboronic Acid 1,3-Propanediol Ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(Pyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pyridine-3-boronic Acid Pinacol Ester (common misnomer); 3-Pyridylboronic Acid Pinacol Ester; 3-Pyridinylboronic Acid Cyclic Ester; 3-Boronopyridine 1,3-Propanediol Cyclic Ester
EINECS	Contact for details

Quality Control

Our Pyridine-3-Boronic Acid 1,3-Propanediol Cyclic Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC/NMR), identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when weighing to prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.