Description

3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Uridine is a key protected nucleoside derivative, specifically designed for oligonucleotide synthesis. This compound is essential for researchers and manufacturers requiring high-purity, reactive intermediates for the controlled assembly of RNA and DNA sequences. It is primarily utilized in the pharmaceutical, biotechnology, and diagnostic sectors for applications in antisense therapy, siRNA development, and molecular biology research.

Application

• Oligonucleotide Synthesis: Serves as a critical building block (phosphoramidite precursor) in solid-phase synthesis of RNA and DNA strands.
• Antisense & siRNA Therapeutics: Used in the research and production of therapeutic oligonucleotides for targeted gene silencing and regulation.
• Diagnostic Probe Development: Enables the creation of labeled probes and primers for PCR, sequencing, and hybridization assays.
• Medicinal Chemistry: Acts as a protected intermediate in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Bioconjugation: Provides a reactive handle for attaching uridine derivatives to other molecules, surfaces, or delivery vehicles.
• Academic & Industrial R&D: A fundamental reagent for exploring nucleic acid chemistry, structure, and function in laboratory settings.

Basic Information

Item	Details
Product Name	3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Uridine
CAS No.	131474-72-1
Molecular Formula	C22H40N2O7Si2
Molecular Weight	500.74 g/mol
Synonyms	1-[(2R,3R,4R,5R)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 2',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine; Uridine, 2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-; TIPDS-protected Uridine; 3',5'-O-TIPDS-Uridine; 2',3'-O-TIPDS-Uridine; Uridine TIPDS ether
EINECS	Contact for details

Quality Control

Every batch of 3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Uridine is manufactured and tested under strict quality management systems. We ensure compliance with high-purity standards suitable for pharmaceutical research and synthesis. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and stability. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.