Description

(3R)-3-(tert-Butyldimethylsilyloxy)Glutaric Acid -1-((R)-(-)-Mandelic Acid Ester is a high-purity, chiral synthetic intermediate of significant importance in advanced organic synthesis. This compound is valued for its role in constructing complex, stereochemically defined molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by fine chemical manufacturers and R&D laboratories specializing in the production of active pharmaceutical ingredients (APIs), agrochemicals, and other high-value specialty chemicals where precise stereocontrol is critical.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs), especially those requiring specific (R)-configurations.
• Asymmetric Synthesis: Used in stereoselective reactions to introduce chiral centers in target molecules for agrochemicals, flavors, and fragrances.
• Peptidomimetic Research: Serves as a precursor for synthesizing peptide analogs and conformationally constrained scaffolds in medicinal chemistry.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for catalytic asymmetric transformations.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	(3R)-3-(tert-Butyldimethylsilyloxy)Glutaric Acid -1-((R)-(-)-Mandelic Acid Ester
CAS No.	131466-61-0
Molecular Formula	C19H30O6Si
Molecular Weight	382.53 g/mol
Synonyms	(R)-3-[(tert-Butyldimethylsilyl)oxy]glutaric acid 1-[(R)-(-)-mandelate]; (3R)-3-[(tert-Butyldimethylsilyl)oxy]pentanedioic acid 1-[(2R)-2-hydroxy-2-phenylacetate]; (R)-3-(TBDMSO)glutaric acid (R)-(-)-mandelic acid ester; TBDMS-protected (R)-3-hydroxyglutaric acid (R)-mandelate; Chiral TBDMS-glutarate mandelate ester
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, and chiral analysis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with each shipment. We support development and cGMP-grade production requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.