Description

Succinimidyl 2-(4-Azido-2,3,5,6-Tetrafluorophenyl)Thiazole-4-Carboxylate is a highly specialized heterobifunctional crosslinking reagent designed for advanced bioconjugation and labeling applications. This compound matters because it combines a photoactivatable aryl azide group with an amine-reactive NHS ester, enabling efficient, light-controlled covalent attachment of biomolecules. It is primarily needed by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and materials surface functionalization.

Application

• Photoaffinity Labeling: Covalent capture of transient protein-protein or protein-ligand interactions upon UV light activation.
• Bioconjugation & ADC Linker Chemistry: Site-specific conjugation of drugs, fluorophores, or other payloads to antibodies, peptides, or proteins.
• Surface Immobilization: Functionalization of biosensor chips, nanoparticles, or other solid supports with bioactive molecules.
• Chemical Proteomics: Identification and profiling of enzyme active sites or binding pockets.
• Polymer & Materials Science: Crosslinking agent for creating novel polymeric networks with photo-responsive properties.
• Diagnostic Reagent Synthesis: Building block for creating advanced diagnostic assays and imaging probes.

Basic Information

Product Name	Succinimidyl 2-(4-Azido-2,3,5,6-Tetrafluorophenyl)Thiazole-4-Carboxylate
CAS No.	131238-06-7
Molecular Formula	C15H5F4N5O4S
Molecular Weight	435.29 g/mol
Synonyms	2,5-Dioxopyrrolidin-1-yl 2-(4-azido-2,3,5,6-tetrafluorophenyl)-1,3-thiazole-4-carboxylate; 4-Azido-2,3,5,6-tetrafluorophenyl thiazole NHS ester; N-Hydroxysuccinimide ester of 2-(4-azido-2,3,5,6-tetrafluorophenyl)thiazole-4-carboxylic acid; Tetrafluorophenyl Azido Thiazole NHS Ester; Heterobifunctional Crosslinker, NHS-Azide; Photoactivatable NHS Ester; Azido-PFPT-NHS; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our Succinimidyl 2-(4-Azido-2,3,5,6-Tetrafluorophenyl)Thiazole-4-Carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the container to reach room temperature in a dark environment before opening to prevent condensation. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.