Description

Succinimidyl n-(4-Azido-2,3,5,6-Tetrafluorobenzoyl)Tyrosinate is a heterobifunctional crosslinking reagent designed for advanced bioconjugation and protein labeling. This compound matters for its ability to facilitate the stable attachment of biomolecules to surfaces or other molecules under controlled conditions, enabling critical research and diagnostic applications. It is primarily needed by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and biosensor fabrication, where precise and efficient crosslinking is paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• Surface Immobilization of Proteins: Covalent attachment of enzymes, antibodies, or other proteins to azide-functionalized chips, beads, or plates for assay development.
• Biomolecule Labeling and Tagging: Introduction of fluorescent dyes, biotin, or other probes onto proteins or peptides via the tyrosine residue.
• Polymer-Protein Conjugate Synthesis: Creating hybrid materials for drug delivery systems or biomedical coatings.
• Crosslinking for Structural Studies: Mapping protein-protein interactions or stabilizing protein complexes for analysis by mass spectrometry.
• Diagnostic Reagent Manufacturing: Production of components for immunoassays and other clinical diagnostic tests.

Basic Information

Product Name	Succinimidyl n-(4-Azido-2,3,5,6-Tetrafluorobenzoyl)Tyrosinate
CAS No.	131238-02-3
Molecular Formula	C20H12F4N4O6
Molecular Weight	480.33 g/mol
Synonyms	N-Succinimidyl 4-Azido-2,3,5,6-tetrafluorobenzoate Tyrosinate; 4-Azido-2,3,5,6-tetrafluorobenzoic Acid N-Hydroxysuccinimide Ester Tyrosinate; SFB Tyrosine NHS Ester; Tetrafluorophenyl Azide Tyrosine Crosslinker; N-(4-Azido-2,3,5,6-tetrafluorobenzoyl)tyrosine N-hydroxysuccinimide ester; Heterobifunctional Crosslinker (NHS ester/Azide); Tyrosine-reactive Photoaffinity Labeling Reagent
EINECS	Contact for details

Quality Control

Our Succinimidyl n-(4-Azido-2,3,5,6-Tetrafluorobenzoyl)Tyrosinate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, IR). Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.