Description

(E)-3-(4-Fluoro-Phenyl)-Acrylic Acid Butyl Ester is a high-purity fluorinated acrylate ester building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and specialty polymers. It is primarily sought by R&D chemists and process development teams in the fine chemical, pharmaceutical, and material science industries for constructing complex molecules with specific electronic and steric properties.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated cinnamate moiety for enhanced bioavailability or metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators where the fluorine atom and acrylate ester group impart desired biological activity.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated monomers used in the manufacture of high-performance liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed as a specialty monomer to introduce fluorine and phenyl groups into acrylic polymers, enhancing properties like chemical resistance, weatherability, and optical clarity.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Heck reaction) for creating complex, conjugated organic structures.
• Flavor & Fragrance Chemistry: Utilized as an intermediate for synthesizing specific aromatic compounds used in high-value fragrance and flavor formulations.

Basic Information

Product Name	(E)-3-(4-Fluoro-Phenyl)-Acrylic Acid Butyl Ester
CAS No.	131061-12-6
Molecular Formula	C₁₃H₁₅FO₂
Molecular Weight	222.26 g/mol
Synonyms	Butyl (E)-3-(4-fluorophenyl)acrylate; trans-4-Fluorocinnamic Acid Butyl Ester; (E)-Butyl 3-(4-fluorophenyl)propenoate; 4-Fluorocinnamic Acid n-Butyl Ester; (E)-3-(p-Fluorophenyl)-2-propenoic Acid Butyl Ester; Butyl 4-Fluorocinnamate; FCA Butyl Ester; BFC
EINECS	Contact for details

Quality Control

Our (E)-3-(4-Fluoro-Phenyl)-Acrylic Acid Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets exacting R&D and production standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Isomeric Purity (E/Z Ratio)	≥ 99:1 (E/Z)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.