Description

(2R, 4R)-4-(Toluene-4-Sulfonyloxy)-1-[Benzyloxycarbonyl]-Pyrrolidine-2-Ethylcarboxylate is a high-purity, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key protected intermediate, enabling the stereoselective construction of complex pharmacophores and fine chemicals. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug candidates, especially protease inhibitors and other nitrogen-based therapeutics.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and constrained amino acid analogs for medicinal chemistry programs.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to introduce defined stereocenters.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and synthetic chemistry.

Basic Information

Item	Detail
Product Name	(2R, 4R)-4-(Toluene-4-Sulfonyloxy)-1-[Benzyloxycarbonyl]-Pyrrolidine-2-Ethylcarboxylate
CAS No.	130830-60-3
Molecular Formula	C22H25NO7S
Molecular Weight	447.50 g/mol
Synonyms	(2R,4R)-1-(Benzyloxycarbonyl)-4-[(4-methylphenyl)sulfonyl]oxy]-2-pyrrolidinecarboxylic acid ethyl ester; (2R,4R)-4-[(4-Methylbenzenesulfonyl)oxy]-1-[(benzyloxy)carbonyl]-2-pyrrolidinecarboxylic acid ethyl ester; Ethyl (2R,4R)-1-(benzyloxycarbonyl)-4-[(4-toluenesulfonyl)oxy]pyrrolidine-2-carboxylate; (2R,4R)-1-Cbz-4-OTs-Pyrrolidine-2-ethyl carboxylate; Cbz-(2R,4R)-4-OTs-Proline ethyl ester; (2R,4R)-4-Tosyloxy-1-Cbz-pyrrolidine-2-ethylcarboxylate; (2R,4R)-1-(Benzyloxycarbonyl)-4-(p-toluenesulfonyloxy)pyrrolidine-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our (2R, 4R)-4-(Toluene-4-Sulfonyloxy)-1-[Benzyloxycarbonyl]-Pyrrolidine-2-Ethylcarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.