Description

(R)-(5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound matters for its role in the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in asymmetric synthesis and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Asymmetric Catalyst Ligand: Serves as a sophisticated ligand framework for developing transition metal catalysts used in enantioselective transformations.
• Chemical Biology Probe: Used in academic and industrial research to study enzyme mechanisms and protein-ligand interactions due to its specific stereochemistry.
• Agrochemical Research: Employed in the discovery and development of new, more selective pesticides and herbicides.
• Material Science: Potential monomer or additive for creating advanced polymers with specific chiral or optical properties.

Basic Information

Item	Detail
Product Name	(R)-(5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone
CAS No.	130775-79-0
Molecular Formula	C11H13N3O
Molecular Weight	203.24 g/mol
Synonyms	(R)-3-(5-Methyl-4,5-dihydro-1H-pyrazole-1-carbonyl)pyridine; (R)-Nicolinamide pyrazoline derivative; (R)-1-(3-Pyridinylcarbonyl)-5-methyl-4,5-dihydro-1H-pyrazole; (R)-1-(Pyridine-3-carbonyl)-5-methyl-4,5-dihydro-1H-pyrazole; (R)-5-Methyl-1-(pyridine-3-carbonyl)-4,5-dihydro-1H-pyrazole; (R)-Enantiomer of 130775-79-0
EINECS	Contact for details

Quality Control

Our production of (R)-(5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (e.e.) verification, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.