Description

n-Formyl-L-Leucine (3S,4S,6S)-3-Hexyltetrahydro-2-Oxo-6-Undecyl-2H-Pyran-4-Yl Ester is a specialized, high-purity synthetic intermediate featuring a complex esterified lactone structure. This compound is critical for advanced research and development, particularly in the synthesis of novel bioactive molecules and complex natural product analogs. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating sophisticated chiral building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for complex target molecules.
• Peptidomimetic Research: Serves as a protected leucine derivative for constructing modified peptide chains and exploring structure-activity relationships.
• Medicinal Chemistry: Used in the synthesis of compound libraries for high-throughput screening against various biological targets.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce specific chiral centers into complex molecular architectures.
• Natural Product Synthesis: An intermediate in the total or semi-synthesis of complex natural products containing lactone and amino acid motifs.
• Bioconjugation Chemistry: Potential use in developing linkers or payloads for antibody-drug conjugates (ADCs) and other targeted therapies.

Basic Information

Product Name	n-Formyl-L-Leucine (3S,4S,6S)-3-Hexyltetrahydro-2-Oxo-6-Undecyl-2H-Pyran-4-Yl Ester
CAS No.	130676-65-2
Molecular Formula	C29H53NO5
Molecular Weight	495.74 g/mol
Synonyms	L-Leucine, N-formyl-, (3S,4S,6S)-3-hexyltetrahydro-2-oxo-6-undecyl-2H-pyran-4-yl ester; (3S,4S,6S)-3-Hexyl-6-undecyltetrahydro-2H-pyran-2,4-diyl bis(2-formamido-4-methylpentanoate) (related structure); Formylleucine Lactone Ester; N-Formyl-L-leucine 4-[(3S,4S,6S)-3-hexyl-6-undecyl-2-oxotetrahydro-2H-pyran-4-yl] ester; A complex lactone ester of N-Formyl-L-Leucine.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and high chemical purity. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are provided with every shipment. We support development projects with custom synthesis and analytical method development to meet specific research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.