Description

Eplivanserin Fumarate CAS NO 130580-02-8 is a high-purity, non-benzodiazepine chemical entity primarily recognized for its pharmacological activity as a selective serotonin receptor antagonist. This compound is of significant interest for research and development within the pharmaceutical sector, particularly for investigating mechanisms related to sleep regulation. It is a critical material for pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in preclinical studies and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and research of advanced drug candidates targeting specific serotonin pathways.
• Preclinical Research & Development: Essential for in vitro and in vivo studies to elucidate pharmacokinetics, pharmacodynamics, and toxicological profiles.
• Biochemical Assay Development: Employed as a tool compound in high-throughput screening and receptor binding assays to discover new drug entities.
• Academic Research: Utilized in university and institutional labs for neuroscience and neuropharmacology studies.
• Formulation Development: Aids in the development of dosage forms during early-stage drug product development.

Basic Information

Product Name	Eplivanserin Fumarate
CAS No.	130580-02-8
Molecular Formula	C₂₄H₂₆FN₃O₆
Molecular Weight	471.48 g/mol
Synonyms	Eplivanserin hemifumarate; SR 46349B; (2Z)-2-Butenedioic acid - N'-[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]-N-(2-methoxyethyl)-1H-indazole-3-carboxamide (2:1); SR-46349B; UNII-2Q7Q55815O; 1H-Indazole-3-carboxamide, N-[2-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-indazol-3-yl]-N-(2-methoxyethyl)-, (2Z)-2-butenedioate (2:1)
EINECS	Contact for details

Quality Control

Our Eplivanserin Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) documenting all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.