Description

(3As,4S,5S,6R,7As)-4-(Ethoxycarbonyl)-6-Ethyl-1-Oxooctahydro-1H-Indene-5-Carboxylic Acid CAS NO 130274-13-4 is a high-purity, stereochemically defined indane derivative used as a critical advanced intermediate in pharmaceutical synthesis. This compound is valued for its complex chiral structure, which serves as a key building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex organic molecules, particularly in the areas of cardiovascular and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of proprietary drug candidates and complex target molecules.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the exploration of new chemical entities.
• Process Chemistry: Serves as a critical starting material or intermediate in the scale-up and optimization of API manufacturing processes.
• Asymmetric Synthesis: Utilized in reactions requiring specific stereochemical control due to its defined (3As,4S,5S,6R,7As) configuration.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(3As,4S,5S,6R,7As)-4-(Ethoxycarbonyl)-6-Ethyl-1-Oxooctahydro-1H-Indene-5-Carboxylic Acid
CAS No.	130274-13-4
Molecular Formula	C16H22O5
Molecular Weight	294.34 g/mol
Synonyms	4-(Ethoxycarbonyl)-6-ethyl-1-oxooctahydro-1H-indene-5-carboxylic acid; (3aR,4S,5S,6R,7aR)-4-(Ethoxycarbonyl)-6-ethyl-1-oxooctahydro-1H-indene-5-carboxylic acid; 1H-Indene-5-carboxylic acid, octahydro-4-(ethoxycarbonyl)-6-ethyl-1-oxo-, (3aR,4S,5S,6R,7aR)-; Ethyl 5-carboxy-6-ethyl-1-oxooctahydro-1H-indene-4-carboxylate (stereoisomer); A key indane-dicarboxylate intermediate.
EINECS	Contact for details

Quality Control

Our (3As,4S,5S,6R,7As)-4-(Ethoxycarbonyl)-6-Ethyl-1-Oxooctahydro-1H-Indene-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.