Description

5-o-tert-Butyldiphenylsilyl-2,3-o-Isopropylidene-D-Lyxono-1,4-Lactone CAS NO 130222-84-3 is a sophisticated, high-purity chiral building block and protected sugar derivative essential for advanced organic synthesis. Its primary value lies in serving as a key intermediate for the preparation of nucleoside analogs, antiviral agents, and other complex bioactive molecules. This compound is critically needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on developing novel therapeutics and exploring carbohydrate chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of nucleoside-based antiviral and anticancer drugs.
• Antiviral Pro-drug Development: Used in the research and production of modified nucleosides targeting viruses such as HIV, Hepatitis B, and herpes viruses.
• Carbohydrate Chemistry Research: Serves as a protected D-lyxono-1,4-lactone derivative for studying glycosylation reactions and synthesizing complex oligosaccharides.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of other high-value, stereochemically defined fine chemicals and natural product analogs.
• Labeled Compound Preparation: Acts as a precursor for introducing isotopic labels (e.g., 13C, 2H) into sugar moieties for metabolic tracing studies.

Basic Information

Product Name	5-o-tert-Butyldiphenylsilyl-2,3-o-Isopropylidene-D-Lyxono-1,4-Lactone
CAS No.	130222-84-3
Molecular Formula	C24H30O5Si
Molecular Weight	426.58 g/mol
Synonyms	5-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-D-lyxono-1,4-lactone; 2,3-O-Isopropylidene-5-O-(tert-butyldiphenylsilyl)-D-lyxono-1,4-lactone; D-Lyxono-1,4-lactone, 5-O-(1,1-dimethylethyl)diphenylsilyl-2,3-O-(1-methylethylidene)-; 5-TBDPS-2,3-O-isopropylidene-D-lyxono-1,4-lactone; Protected D-Lyxono-1,4-lactone; TBDPS-protected lyxono lactone; tert-Butyldiphenylsilyl lyxono lactone ketal
EINECS	Contact for details

Quality Control

Every batch of 5-o-tert-Butyldiphenylsilyl-2,3-o-Isopropylidene-D-Lyxono-1,4-Lactone is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical purity and correct stereochemical configuration. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your GMP and research documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such reagents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.