Description

2-Amino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid Methyl Ester is a high-value, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its core value lies in the combination of a reactive amino ester functional group with the unique electronic and steric properties imparted by the trifluoromethylphenyl moiety, enabling precise molecular design. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex intermediates where fluorine substitution is strategically advantageous.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the CF3 group enhances biological activity and environmental stability.
• Peptidomimetics & Bioactive Peptides: Incorporation into peptide chains to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Research: A valuable tool for probing enzyme mechanisms and studying protein-protein interactions via site-specific labeling.
• Material Science Precursor: Potential use in the synthesis of specialized polymers and advanced organic materials with tailored properties.

Basic Information

Product Name	2-Amino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid Methyl Ester
CAS No.	129941-39-5
Molecular Formula	C11H12F3NO2
Molecular Weight	247.21 g/mol
Synonyms	Methyl 2-amino-3-[4-(trifluoromethyl)phenyl]propanoate; (S)- or (R)-Methyl 2-amino-3-(4-(trifluoromethyl)phenyl)propanoate (enantiomers); 4-(Trifluoromethyl)phenylalanine methyl ester; α-Amino-4-(trifluoromethyl)benzenepropanoic acid methyl ester; 2-Amino-3-(4-trifluoromethylphenyl)propionic acid methyl ester; Methyl 2-amino-3-(α,α,α-trifluoro-p-tolyl)propionate; p-Trifluoromethylphenylalanine methyl ester; F3C-Phe-OMe
EINECS	Contact for details

Quality Control

Our 2-Amino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity determination, to ensure it meets the exacting standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing identity, purity (typically >97% by HPLC), enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (for specified enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.