Description

2,3,4-Tri-o-Acetyl-α-L-Fucopyranosyl Fluoride is a specialized, high-purity glycosyl fluoride derivative used as a key building block in synthetic carbohydrate chemistry. This compound matters because it serves as a crucial glycosyl donor for the stereoselective construction of complex oligosaccharides and glycoconjugates. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, vaccines, and diagnostic tools, where precise control over glycosidic bond formation is essential. Its role is critical in advancing glycobiology and medicinal chemistry research.

Application

• Glycosylation Reagent: Acts as a critical glycosyl donor in chemical and enzymatic synthesis of fucose-containing oligosaccharides and glycoproteins.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly in oncology and immunology where fucose motifs play a role.
• Glycoconjugate Synthesis: Essential for creating defined glycan structures attached to proteins, lipids, or other carriers for vaccine development.
• Biochemical Probe Development: Employed to synthesize labeled or modified fucose derivatives for studying biological recognition processes.
• Enzymatic Substrate: Serves as a substrate for glycosyltransferases and glycosidases in mechanistic and inhibition studies.
• Material Science Research: Used in the synthesis of carbohydrate-based polymers and surfaces with specific biological recognition properties.

Basic Information

Product Name	2,3,4-Tri-o-Acetyl-α-L-Fucopyranosyl Fluoride
CAS No.	129864-97-7
Molecular Formula	C₁₂H₁₇FO₈
Molecular Weight	308.26 g/mol
Synonyms	Tri-O-acetyl-α-L-fucopyranosyl fluoride; α-L-Fucopyranosyl fluoride, 2,3,4-triacetate; 1-Fluoro-2,3,4-tri-O-acetyl-α-L-fucopyranose; 2,3,4-Tri-O-acetyl-α-L-fucopyranosyl fluoride; (2R,3S,4S,5R,6S)-5-Methyl-2-(((2R,3S,4S,5R,6S)-5-methyl-2,3,4-tris(acetyloxy)tetrahydro-2H-pyran-6-yl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate (related IUPAC); Ac₃FucαF (common abbreviation); L-Fucose tetraacetate α-fluoride
EINECS	Contact for details

Quality Control

Our 2,3,4-Tri-o-Acetyl-α-L-Fucopyranosyl Fluoride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.