Description

5'-o-(tert-Butyldimethylsilyl)-5-Fluoro-2'-Deoxyuridine is a key protected nucleoside derivative used as a critical synthetic intermediate in the development of novel antiviral and anticancer pharmaceuticals. This compound matters because it provides a strategically protected hydroxyl group, enabling precise and efficient synthesis of complex nucleotide analogs. Pharmaceutical researchers and fine chemical manufacturers need this high-purity building block for advanced drug discovery programs, particularly in the development of fluorinated pyrimidine-based therapeutics. Its reliable quality is essential for ensuring the reproducibility and success of downstream synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) for antiviral and anticancer drugs.
• Antiviral Drug Research: Used in the development of nucleotide analogs targeting viral polymerases, particularly for herpesviruses and other DNA viruses.
• Oncology Drug Discovery: Serves as a precursor for fluoropyrimidine-based chemotherapeutic agents, which are antimetabolites that interfere with DNA synthesis in cancer cells.
• Prodrug Synthesis: Employed in creating prodrug forms of nucleoside analogs to improve bioavailability and targeted delivery.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and polymerase function.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., 13C, 15N, 18F) compounds for metabolic tracing and imaging studies.
• Oligonucleotide Chemistry: Used in the solid-phase or solution-phase synthesis of modified oligonucleotides for therapeutic and diagnostic applications.

Basic Information

Product Name	5'-o-(tert-Butyldimethylsilyl)-5-Fluoro-2'-Deoxyuridine
CAS No.	129816-30-4
Molecular Formula	C16H27FN2O5Si
Molecular Weight	374.49 g/mol
Synonyms	5-Fluoro-2'-deoxyuridine 5'-(tert-butyldimethylsilyl) ether; 5'-O-TBDMS-5-Fluoro-2'-deoxyuridine; 5-FdUrd 5'-O-TBDMS; 5-Fluoro-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-deoxyuridine; 5-Fluoro-2'-deoxy-5'-O-(tert-butyldimethylsilyl)uridine; TBDMS-5-Fluoro-2'-deoxyuridine; 5-FDU TBDMS ether; 1-[(2R,4S,5R)-4-[(tert-Butyldimethylsilyl)oxy]-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5'-o-(tert-Butyldimethylsilyl)-5-Fluoro-2'-Deoxyuridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing all critical quality attributes. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.