Description

S-Acetylthioglycolic Acid Pentafluorophenyl Ester is a high-purity, specialized chemical reagent designed for advanced synthetic applications. This compound serves as a critical building block for the introduction of thiol-reactive groups, enabling precise bioconjugation and material functionalization. It is essential for researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors who require reliable, high-quality intermediates for developing targeted therapies, diagnostic probes, and functional polymers.

Application

• Peptide and Protein Modification: Acts as a key reagent for site-specific labeling and cross-linking of biomolecules.
• Antibody-Drug Conjugate (ADC) Synthesis: Used in the development of linker-payload constructs for targeted cancer therapies.
• Polymer Functionalization: Enables the introduction of reactive thiol handles onto polymer backbones for creating smart materials.
• Surface Immobilization Chemistry: Facilitates the covalent attachment of biomolecules to chips, beads, and other solid supports for biosensors and assays.
• Fluorescent Probe Synthesis: Employed in the preparation of thiol-reactive fluorescent dyes for cellular imaging and diagnostics.
• Protecting Group Strategy: Serves as a protected thiol precursor in multi-step organic syntheses requiring orthogonal deprotection.

Basic Information

Product Name	S-Acetylthioglycolic Acid Pentafluorophenyl Ester
CAS No.	129815-48-1
Molecular Formula	C10H5F5O3S
Molecular Weight	300.20 g/mol
Synonyms	2-(Acetylthio)acetic Acid Pentafluorophenyl Ester; S-Acetylmercaptoacetic Acid Pentafluorophenyl Ester; Pentafluorophenyl S-Acetylthioglycolate; Acetylthioglycolic Acid PFP Ester; PFP-SATA; (Acetylthio)acetic Acid 2,3,4,5,6-Pentafluorophenyl Ester; Pentafluorophenyl 2-(Acetylthio)acetate
EINECS	Contact for details

Quality Control

Our S-Acetylthioglycolic Acid Pentafluorophenyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.