Description

L-Azetidine-2-Carboxylic Acid T-Butyl Ester is a protected amino acid derivative that serves as a crucial chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, acid-labile protecting group for the azetidine carboxylic acid moiety, enabling selective reactions in complex molecular construction. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for peptidomimetics and constrained analogs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel drug candidates, especially protease inhibitors and receptor modulators.
• Peptidomimetics Synthesis: Used to introduce the conformationally restricted azetidine ring into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Active Ingredient Development: Building block for creating new generations of herbicides, fungicides, and insecticides with improved specificity.
• Chemical Biology & Proteomics: Tool compound for studying enzyme mechanisms and designing activity-based probes.
• Material Science Research: Monomer for specialty polymers and advanced materials requiring specific stereochemistry.
• Academic & Contract Research: Critical reagent for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	L-Azetidine-2-Carboxylic Acid T-Butyl Ester
CAS No.	129740-14-3
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid; (S)-2-Carboxyazetidine-1-carboxylic acid tert-butyl ester; L-Azetidine-2-carboxylic acid 1-tert-butyl ester; Boc-L-Aze-OH; tert-Butyl L-azetidine-2-carboxylate; (S)-Azetidine-2-carboxylic acid tert-butyl ester; 1-Boc-L-azetidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our L-Azetidine-2-Carboxylic Acid T-Butyl Ester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is stable under inert atmosphere but should be protected from strong acids and moisture to prevent deprotection or degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.