Description

Boc-His(3-Bom)-Osu CAS NO 129672-10-2 is a protected amino acid derivative, specifically an N-Boc-histidine derivative with a benzyloxymethyl (Bom) group on the imidazole side chain, activated as an N-hydroxysuccinimide (Osu) ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of histidine residues while preventing unwanted side reactions. It is primarily used by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected and activated monomer for the sequential assembly of peptide chains, particularly for introducing histidine residues.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Used to label proteins, antibodies, or other biomolecules with histidine-containing tags or probes via the reactive NHS ester group.
• Combinatorial Chemistry: Serves as a building block in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Employed in biochemistry and molecular biology studies to investigate protein structure, function, and protein-protein interactions.
• Production of Custom Peptides: Essential for contract research organizations (CROs) and CDMOs manufacturing bespoke peptides for clients.

Basic Information

Item	Details
Product Name	Boc-His(3-Bom)-Osu
CAS No.	129672-10-2
Molecular Formula	C₂₂H₂₈N₄O₇
Molecular Weight	460.48 g/mol
Synonyms	N-α-Boc-N-π-benzyloxymethyl-L-histidine N-hydroxysuccinimide ester; Boc-L-histidine(3-Bom)-OH succinimidyl ester; tert-Butyloxycarbonyl-L-histidine(3-benzyloxymethyl)-OSu; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1-(benzyloxymethyl)-1H-imidazol-4-yl)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; Boc-His(Bom)-OSu; Boc-His(3-BzlOM)-OSu; Protected Histidine NHS Ester
EINECS	Contact for details

Quality Control

Our Boc-His(3-Bom)-Osu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.