Description

Bizelesin is a synthetic, sequence-selective DNA minor groove alkylating agent belonging to the cyclopropylpyrroloindole (CPI) class of compounds. This compound is of significant interest in advanced pharmaceutical research due to its potent antitumor properties and its role as a tool compound for studying DNA interaction mechanisms. It is primarily utilized by research institutions and pharmaceutical developers engaged in oncology drug discovery, molecular biology, and the development of novel chemotherapeutic agents.

Application

• Oncology Research & Drug Discovery: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel antitumor therapies.
• Biochemical Mechanism Studies: Used as a probe to investigate DNA alkylation, sequence specificity, and the cellular response to DNA damage.
• Pharmaceutical Intermediate: Acts as a critical synthetic intermediate in the preparation of more complex therapeutic candidates or conjugates.
• Academic Research: Employed in university and institutional labs for studies in medicinal chemistry, pharmacology, and cancer biology.
• Standards & Controls: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Bizelesin
CAS No.	129655-21-6
Molecular Formula	C39H44N6O6
Molecular Weight	692.81 g/mol
Synonyms	U-77779; NSC-D-615703; (+)-Bizelesin; (1S,8S)-1,8-Bis({4-[(2-{[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1H-indol-3-yl)propanoyl]amino}ethyl)carbamoyl]phenyl}carbamoyl)-2,7-diazabicyclo[4.4.0]deca-3,5,9-triene-4,6,10-trione; Cyclopropylpyrroloindole analog U-77779
EINECS	Contact for details

Quality Control

Our Bizelesin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.