Description

tert-Butyl 7-Oxo-5-Azaspiro[2.4]heptane-5-carboxylate is a high-value, protected spirocyclic amino acid derivative used as a critical building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of constrained peptidomimetics.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of spirocyclic drug candidates targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Medicinal Chemistry Research: Used to introduce conformational rigidity into peptide backbones, creating novel peptidomimetics with enhanced metabolic stability and receptor selectivity.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate in the development and optimization of scalable synthetic routes for target molecules.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function, protein-protein interactions, and biological pathways.
• Academic & Industrial R&D: Employed in exploratory synthesis for the discovery of new chemical entities with potential therapeutic value.

Basic Information

Product Name	tert-Butyl 7-Oxo-5-Azaspiro[2.4]heptane-5-Carboxylate
CAS No.	129321-62-6
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	5-*tert*-Butoxycarbonyl-7-oxo-5-azaspiro[2.4]heptane; 5-Boc-7-oxo-5-azaspiro[2.4]heptane; *tert*-Butyl 7-oxo-5-azaspiro[2.4]heptane-5-carboxylate; 7-Oxo-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester; 5-Azaspiro[2.4]heptane-7-one, 5-[(1,1-dimethylethoxy)carbonyl]-; Boc-5-azaspiro[2.4]heptan-7-one; 129321-62-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Oxo-5-Azaspiro[2.4]heptane-5-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.