Description

Calcium L-Methylfolate is the calcium salt of the biologically active form of folate, (6S)-5-methyltetrahydrofolic acid. This compound is critical for providing a highly bioavailable source of folate, which is essential for numerous cellular processes including DNA synthesis and amino acid metabolism. It is primarily utilized by manufacturers in the pharmaceutical and nutraceutical industries for formulating advanced dietary supplements and medical foods.

Application

• Pharmaceutical Formulations: Active ingredient in prescription and over-the-counter medications for folate deficiency and related metabolic support.
• Dietary Supplements: Key component in high-quality multivitamins, prenatal vitamins, and specialized nutraceuticals targeting methylation support.
• Medical Nutrition: Fortification of medical foods and clinical nutrition products for patients with specific metabolic needs or malabsorption issues.
• Functional Food & Beverage: Used in the fortification of foods and drinks where a stable, bioavailable form of folate is required.
• Research & Development: Reference standard and biochemical reagent in life science research, particularly in studies of folate metabolism and homocysteine regulation.

Basic Information

Product Name	Calcium L-Methylfolate
CAS No.	129025-21-4
Molecular Formula	C20H23CaN7O6
Molecular Weight	497.53 g/mol
Synonyms	(6S)-5-Methyltetrahydrofolic acid, calcium salt; L-Methylfolate Calcium; Metafolin®; Levomefolic acid calcium salt; (6S)-5-MTHF calcium; 5-Methyltetrahydrofolate calcium; Deplin® (active ingredient); Quatrefolic® (active form).
EINECS	Contact for details

Quality Control

Our Calcium L-Methylfolate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical and nutraceutical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Microbiological Analysis	Meets Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.