Description

11-Ethyl-16-Fluoroestradiol is a synthetic, fluorinated derivative of estradiol, a key steroid hormone. This compound is engineered to offer enhanced metabolic stability and receptor binding affinity, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly in the fields of endocrinology, oncology, and nuclear medicine.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel steroidal drugs and targeted radiopharmaceuticals.
• Biochemical Research: Used as a reference standard or probe in studies of estrogen receptor (ER) binding, function, and signaling pathways.
• Drug Discovery: Serves as a precursor in medicinal chemistry programs aimed at developing new hormone therapies with improved pharmacokinetic profiles.
• Diagnostic Agent Development: Potential use in the development of fluorinated tracers for Positron Emission Tomography (PET) imaging.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental endocrinology and steroid chemistry research.

Basic Information

Product Name	11-Ethyl-16-Fluoroestradiol
CAS No.	129000-39-1
Molecular Formula	C20H27FO2
Molecular Weight	318.43 g/mol
Synonyms	11-Ethyl-16α-fluoroestradiol; 16-Fluoro-11-ethylestradiol; 16α-Fluoro-11β-ethylestra-1,3,5(10)-triene-3,17β-diol; Estra-1,3,5(10)-triene-3,17-diol, 11-ethyl-16-fluoro-, (11β,16α,17β)-; 11β-Ethyl-16α-fluoro-17β-estradiol
EINECS	Contact for details

Quality Control

Our 11-Ethyl-16-Fluoroestradiol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.