Description

11-(2-Fluoroethyl)Estradiol is a fluorinated derivative of the natural estrogen hormone, estradiol, designed for enhanced metabolic stability and receptor binding affinity. This compound is a critical intermediate in the research and development of novel radiopharmaceuticals and targeted therapeutics. It is primarily utilized by pharmaceutical R&D teams, radiochemistry laboratories, and academic institutions focused on oncology and endocrinology.

Application

• Radiopharmaceutical Precursor: A key building block for synthesizing fluorine-18 (18F) labeled tracers for Positron Emission Tomography (PET) imaging.
• Oncology Research: Used in the development of targeted therapies and diagnostic agents for estrogen receptor-positive (ER+) cancers, such as breast cancer.
• Endocrinology Studies: Serves as a research chemical for investigating estrogen receptor signaling pathways and hormone metabolism.
• Molecular Probe Synthesis: Employed to create labeled analogs for studying drug-receptor interactions and biodistribution.
• Pharmaceutical Intermediate: An advanced intermediate in the synthesis of experimental therapeutic agents with modified pharmacokinetic profiles.

Basic Information

Product Name	11-(2-Fluoroethyl)Estradiol
CAS No.	129000-35-7
Molecular Formula	C20H27FO2
Molecular Weight	318.43 g/mol
Synonyms	11β-(2-Fluoroethyl)estradiol; 11β-(2-Fluoroethyl)-17β-estradiol; 17β-Hydroxy-11β-(2-fluoroethyl)estra-1,3,5(10)-trien-3-ol; Estra-1,3,5(10)-triene-3,17β-diol, 11β-(2-fluoroethyl)-, (17β)-; 11-Fluoroethylestradiol; FE-E2
EINECS	Contact for details

Quality Control

Our 11-(2-Fluoroethyl)Estradiol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.