Description

(2R)-2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidine is a high-purity, chiral pyrrolidinone derivative featuring a tert-butyldimethylsilyl (TBDMS) protecting group, making it a critical advanced intermediate in sophisticated organic synthesis. This compound matters because it provides a protected chiral handle for the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs), natural products, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Used in the stereocontrolled construction of complex molecular architectures due to its defined (R)-configuration at the 2-position.
• Protecting Group Strategy: The TBDMS ether moiety serves as a robust protecting group for the primary alcohol, enabling selective reactions at other functional sites within the molecule.
• Lactam Chemistry: The 5-oxo-pyrrolidine (γ-lactam) core is a privileged structure in medicinal chemistry, utilized in developing protease inhibitors and other enzyme-targeted therapies.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial manufacturing.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects undertaken by CDMOs (Contract Development and Manufacturing Organizations).

Basic Information

Product Name	(2R)-2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidine
CAS No.	128899-30-9
Molecular Formula	C12H23NO2Si
Molecular Weight	241.40 g/mol
Synonyms	(R)-2-(((tert-Butyldimethylsilyl)oxy)methyl)-5-oxopyrrolidine; (R)-2-((tert-Butyldimethylsilyloxy)methyl)-2-pyrrolidinone; (R)-N-Boc-2-((tert-butyldimethylsilyloxy)methyl)-5-oxopyrrolidine (common error); (2R)-2-[[(tert-Butyldimethylsilyl)oxy]methyl]-5-pyrrolidinone; TBDMS-protected (R)-2-hydroxymethyl-γ-butyrolactam; (R)-2-((TBDMS-O)CH2)-γ-butyrolactam; (R)-2-((tert-Butyldimethylsilyloxy)methyl)-2-pyrrolidin-5-one
EINECS	Contact for details

Quality Control

Our (2R)-2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity (HPLC/GC), chiral excess, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.