Description

Cyclopropanecarboxylic Acid, 1-Amino-2,2-Dimethyl-, Trimethylsilyl Ester (9Ci) is a specialized organosilicon-protected amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its unique sterically hindered cyclopropane and amino functionality, which is protected as a stable trimethylsilyl ester for handling and reactivity control. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, including novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the bioactive cyclopropane motif.
• Peptidomimetics & Conformationally Restricted Peptides: The 1-amino-2,2-dimethylcyclopropanecarboxylic acid scaffold is incorporated to induce specific three-dimensional structures and enhance metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Potential monomer or modifier for creating specialized polymers with unique thermal or mechanical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring high-purity, advanced intermediates.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-Amino-2,2-Dimethyl-, Trimethylsilyl Ester (9Ci)
CAS No.	128753-46-8
Molecular Formula	C9H19NO2Si
Molecular Weight	201.34 g/mol
Synonyms	1-Amino-2,2-dimethylcyclopropanecarboxylic Acid Trimethylsilyl Ester; (1-Amino-2,2-dimethylcyclopropyl)carboxylic Acid TMS Ester; Trimethylsilyl 1-Amino-2,2-dimethylcyclopropanecarboxylate; 2,2-Dimethyl-1-aminocyclopropanecarboxylic Acid Trimethylsilyl Ester; TMS-ADCP; 1-((Trimethylsilyl)oxy)-2,2-dimethyl-1-cyclopropanecarbonitrile (precursor related); Amino-dimethylcyclopropane TMS ester
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarboxylic Acid, 1-Amino-2,2-Dimethyl-, Trimethylsilyl Ester (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC, GC, NMR, and chiral analysis, to confirm identity, purity, and enantiomeric excess where applicable. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We operate under a quality management system and can supply material compliant with ISO and cGMP standards for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). Store under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (if applicable)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.