Description

4-Bromomethyl-3-Fluorobenzoic Acid Methyl Ester is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound matters for its dual functional groups, which allow for versatile derivatization, making it a critical intermediate in the development of complex molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromomethyl group is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.
• Peptide Mimetics & Bio-conjugation: Utilized for introducing fluorinated benzyl groups into peptides or for creating linkers in antibody-drug conjugates (ADCs).
• Chemical Research & Process Development: Employed in academic and industrial R&D labs for method development and exploring new synthetic pathways involving fluorinated aromatics.

Basic Information

Product Name	4-Bromomethyl-3-Fluorobenzoic Acid Methyl Ester
CAS No.	128577-47-9
Molecular Formula	C10H8BrFO2
Molecular Weight	259.07 g/mol
Synonyms	Methyl 4-(Bromomethyl)-3-fluorobenzoate; 3-Fluoro-4-(bromomethyl)benzoic Acid Methyl Ester; Benzoic acid, 4-(bromomethyl)-3-fluoro-, methyl ester; Methyl 3-fluoro-4-(bromomethyl)benzoate; 4-Bromomethyl-3-fluorobenzoic acid methyl ester; 128577-47-9; 3-Fluoro-4-bromomethylbenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Bromomethyl-3-Fluorobenzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.