Description

5-Bromo-1-(Triisopropylsilyl)-1H-Indole is a high-value, organosilicon-protected indole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a reactive bromine handle and a robust silyl protecting group, enabling precise, multi-step synthesis of complex heterocyclic compounds. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel indole-based drug candidates, including kinase inhibitors, serotonin receptor modulators, and anti-cancer agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators that leverage the indole scaffold.
• Material Science Precursor: Serves as a monomer or functional unit in the creation of organic semiconductors, conductive polymers, and advanced OLED materials.
• Cross-Coupling Reactions: The bromine atom is an ideal site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to introduce complex aryl and heteroaryl groups.
• Directed Metalation & Functionalization: The triisopropylsilyl (TIPS) group directs ortho-lithiation, allowing for further functionalization of the indole ring system.
• Academic & Contract Research: A valuable reagent for methodology development and total synthesis projects in university and CRO laboratories.

Basic Information

Product Name	5-Bromo-1-(Triisopropylsilyl)-1H-Indole
CAS No.	128564-66-9
Molecular Formula	C17H26BrNSi
Molecular Weight	352.39 g/mol
Synonyms	1H-Indole, 5-bromo-1-[tris(1-methylethyl)silyl]-; 5-Bromo-1-(triisopropylsilyl)indole; 5-Bromo-1-TIPS-indole; 5-Bromo-1-[(triisopropylsilyl)]-1H-indole; 1-Triisopropylsilyl-5-bromoindole; TIPS-5-Bromoindole; 5-Br-1-TIPS-indole; 128564-66-9
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(Triisopropylsilyl)-1H-Indole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of GMP environments for pharmaceutical intermediates and ISO standards for industrial chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Purity (GC)	≥96.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.