Description

5-Methoxypodophyllotoxin is a semi-synthetic derivative of podophyllotoxin, a naturally occurring lignan with significant biological activity. This compound serves as a crucial intermediate in the synthesis of more complex chemotherapeutic agents and is valued for its potent cytotoxic properties. It is primarily utilized by pharmaceutical research and development organizations, as well as by manufacturers of active pharmaceutical ingredients (APIs) for oncology applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of etoposide, teniposide, and other podophyllotoxin-derived anticancer drugs.
• Biochemical Research: Used as a reference standard and tool compound in studies of tubulin polymerization inhibition and cell cycle arrest.
• Anticancer Agent Development: Serves as a lead compound for the development of novel chemotherapeutic agents targeting various cancers.
• Natural Product Chemistry: Employed in the semi-synthetic modification of natural products to enhance efficacy or reduce toxicity.
• Academic Research: Utilized in university and institutional labs for pharmacological and mechanistic studies.

Basic Information

Product Name	5-Methoxypodophyllotoxin
CAS No.	128443-52-7
Molecular Formula	C23H24O9
Molecular Weight	444.43 g/mol
Synonyms	5-Methoxy-podophyllotoxin; 5-O-Methylpodophyllotoxin; NSC 354646; 4-[(1R,2R,3R,4R)-4-Hydroxy-1-(hydroxymethyl)-6-methoxy-7,8-methylenedioxy-1,2,3,4-tetrahydronaphthalen-2-yl]-2,6-dimethoxyphenol; Podophyllotoxin, 5-methoxy-
EINECS	Contact for details

Quality Control

Our 5-Methoxypodophyllotoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.