Description

Methyl 6-(Boc-Amino)Hexanoate is a versatile and high-purity protected amino acid ester building block, essential for advanced organic synthesis. Its core value lies in providing a reactive carboxylic acid methyl ester and a Boc-protected primary amine, enabling precise, multi-step molecular construction. This compound is critically needed by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as peptide synthesis, linker chemistry, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediates: A key building block in the synthesis of complex drug molecules, particularly for introducing spacer arms and functional handles.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry to incorporate 6-aminohexanoic acid (Ahx) residues with orthogonal protection.
• Linker and Spacer Chemistry: Essential for creating polyethylene glycol (PEG) alternatives and controlled-length carbon chain linkers in bioconjugation and prodrug design.
• Protease Substrate Mimetics: Serves as a precursor for synthesizing fluorogenic and chromogenic substrates used in enzyme activity assays.
• Polymer Modification: Employed to introduce protected amine functionalities into polymer backbones for subsequent functionalization.
• Chemical Biology Probes: Utilized in the development of activity-based probes and affinity labels for target identification and validation.

Basic Information

Product Name	Methyl 6-(Boc-Amino)Hexanoate
CAS No.	128372-97-4
Molecular Formula	C₁₂H₂₃NO₄
Molecular Weight	245.32 g/mol
Synonyms	6-[(tert-Butoxycarbonyl)amino]hexanoic acid methyl ester; Methyl 6-[(tert-butoxycarbonyl)amino]hexanoate; Boc-6-Ahx-OMe; Boc-Ahx-OMe; N-Boc-6-aminohexanoic acid methyl ester; N-(tert-Butoxycarbonyl)-6-aminohexanoic acid methyl ester; Methyl N-Boc-6-aminohexanoate; Boc-NH-(CH2)5-COOCH3
EINECS	Contact for details

Quality Control

Our Methyl 6-(Boc-Amino)Hexanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP intermediate applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific customer specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.