Description

Propanoic Acid, 2-Isocyanato-, Ethyl Ester, (R)- (9Ci) is a chiral isocyanate derivative, a high-value building block for the synthesis of optically active compounds. Its primary commercial value lies in its role as a key intermediate for introducing the (R)-configured α-isocyanato ester moiety into complex molecular architectures. This product is essential for research and production in advanced pharmaceutical development and fine chemical synthesis, where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the production of active pharmaceutical ingredients (APIs), particularly in the synthesis of protease inhibitors, antiviral agents, and other stereospecific drugs.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, improving reaction selectivity and yield.
• Polymer Modification: Employed to introduce reactive isocyanate and ester functionalities into specialty polymers, polyurethanes, and coatings to impart specific properties.
• Peptidomimetics Research: Integral for constructing peptide analogs and peptidomimetics in medicinal chemistry and biochemical research.
• Fine Chemical Production: Utilized in the multistep synthesis of complex natural products, flavors, and fragrances requiring precise stereochemistry.

Basic Information

Product Name	Propanoic Acid, 2-Isocyanato-, Ethyl Ester, (R)- (9Ci)
CAS No.	128302-68-1
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	(R)-Ethyl 2-Isocyanatopropanoate; (R)-2-Isocyanatopropionic Acid Ethyl Ester; D-2-Isocyanatopropionic Acid Ethyl Ester; Ethyl (R)-2-Isocyanatopropionate; (R)-α-Isocyanatopropionic Acid Ethyl Ester; Ethyl (R)-(-)-2-Isocyanatopropanoate; NSC 405124; (R)-Propanoic acid, 2-isocyanato-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of our (R)-Ethyl 2-Isocyanatopropanoate is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and enantiomeric excess meet the stringent requirements of advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications for assay, chiral purity (enantiomeric excess), and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Due to its highly volatile and easily oxidized nature, the container must be kept tightly sealed when not in use and stored at recommended temperatures of 2-8°C for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials such as strong acids, bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.