Description

(R)-3-Hydroxyglutarate Ethyl tert-Butyl is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. This compound is valued for its defined stereochemistry, which is critical for producing enantiomerically pure pharmaceuticals and fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of enantiomerically pure drugs, particularly for cardiovascular and metabolic disease targets.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to construct complex molecular architectures with high optical purity.
• Biochemical Research: Serves as a precursor or standard in metabolic pathway studies and enzyme inhibition research.
• Agrochemical Development: Employed in the synthesis of chiral active ingredients for advanced crop protection agents.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals where specific stereochemistry is required for functionality.

Basic Information

Product Name	(R)-3-Hydroxyglutarate Ethyl tert-Butyl
CAS No.	128237-30-9
Molecular Formula	C11H20O5
Molecular Weight	232.27 g/mol
Synonyms	(R)-Ethyl 3-Hydroxy-5-tert-butoxy-5-oxopentanoate; (R)-Ethyl 3-Hydroxy-5-((tert-butoxy)carbonyl)pentanoate; (R)-3-Hydroxy-5-tert-butoxy-5-oxopentanoic Acid Ethyl Ester; Ethyl (R)-3-Hydroxy-5-(tert-butoxy)-5-oxopentanoate; (R)-3-Hydroxyglutaric Acid 1-tert-Butyl 5-Ethyl Ester; (R)-HGEtBu; (R)-Ethyl 3-Hydroxyglutarate tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our (R)-3-Hydroxyglutarate Ethyl tert-Butyl is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to meet the stringent requirements of advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.