Description

Ethyl 2-Methyl-4,4,4-Trifluorocrotonate is a versatile fluorinated organic ester, a key building block in advanced chemical synthesis. Its value lies in the unique reactivity of the trifluoromethylated crotonate structure, enabling the efficient introduction of fluorine atoms into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl groups for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine moiety enhances biological activity and environmental persistence.
• Fluorinated Material Precursor: Serves as a monomer or building block for creating specialty polymers, coatings, and liquid crystals with unique thermal, chemical, and surface properties.
• Organic Synthesis Reagent: Employed in Michael additions, cycloadditions, and other carbon-carbon bond-forming reactions to construct complex, fluorinated molecular architectures.
• Chemical Research & Development: A valuable tool for medicinal and process chemists exploring new synthetic pathways and fluorine chemistry in academic and industrial R&D settings.

Basic Information

Product Name	Ethyl 2-Methyl-4,4,4-Trifluorocrotonate
CAS No.	128227-97-4
Molecular Formula	C7H9F3O2
Molecular Weight	182.14 g/mol
Synonyms	Ethyl 2-Methyl-4,4,4-Trifluorobut-2-enoate; 4,4,4-Trifluoro-2-methyl-2-butenoic Acid Ethyl Ester; 2-Butenoic acid, 4,4,4-trifluoro-2-methyl-, ethyl ester; Ethyl 4,4,4-Trifluoro-2-methylcrotonate; 2-Methyl-4,4,4-trifluorocrotonic Acid Ethyl Ester; TFMC Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Methyl-4,4,4-Trifluorocrotonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed and at a consistent, moderate temperature (recommended 15-25°C).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.380 - 1.390
Density (20°C)	1.20 - 1.30 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.