Description

3-Piperidinecarboxylic Acid, 4-Oxo-1-(Triphenylmethyl)-, Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific piperidine and trityl-protected amine structure. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in process development and scale-up for new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel drug molecules, especially in medicinal chemistry research.
• Protecting Group Chemistry: The triphenylmethyl (trityl) group is utilized for the temporary protection of amine functionalities during complex synthetic sequences.
• Process Development & Scale-Up: Used in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing.
• Neurological & CNS Drug Research: A valuable scaffold for developing compounds that interact with central nervous system receptors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.
• Academic & Industrial R&D: Employed in discovery chemistry for creating new chemical entities and exploring structure-activity relationships.

Basic Information

Product Name	3-Piperidinecarboxylic Acid, 4-Oxo-1-(Triphenylmethyl)-, Methyl Ester
CAS No.	127956-05-2
Molecular Formula	C26H25NO3
Molecular Weight	399.48 g/mol
Synonyms	1-Trityl-4-oxopiperidine-3-carboxylic acid methyl ester; Methyl 1-trityl-4-oxopiperidine-3-carboxylate; 4-Oxo-1-tritylpiperidine-3-carboxylic acid methyl ester; 1-(Triphenylmethyl)-4-oxo-3-piperidinecarboxylic acid methyl ester; 3-Carbomethoxy-1-trityl-4-piperidone; Methyl 4-oxo-1-(triphenylmethyl)piperidine-3-carboxylate; 1-Trityl-4-piperidone-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Piperidinecarboxylic Acid, 4-Oxo-1-(Triphenylmethyl)-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to minimize exposure to atmospheric humidity. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.