Description

Ethyl D-Norleucinate Hydrochloride is a high-purity chiral building block and protected amino acid derivative. This compound is essential for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control for advanced research and development. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on medicinal chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected D-configured norleucine derivative.
• Medicinal Chemistry Research: Serves as a crucial building block for constructing peptide libraries and exploring structure-activity relationships (SAR).
• Bioconjugation & Labeling: The ethyl ester group provides a handle for further chemical modification and conjugation in probe development.
• Biochemical Research: Employed in studies investigating enzyme specificity, metabolic pathways, and protein-protein interactions.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Ethyl D-Norleucinate Hydrochloride
CAS No.	127641-81-0
Molecular Formula	C8H18ClNO2
Molecular Weight	195.69 g/mol
Synonyms	D-Norleucine ethyl ester hydrochloride; (R)-2-Aminohexanoic acid ethyl ester hydrochloride; Ethyl (R)-2-aminohexanoate hydrochloride; Ethyl D-2-aminohexanoate hydrochloride; D-2-Aminohexanoic acid ethyl ester hydrochloride; D-Nle-OEt·HCl; (R)-Norleucine ethyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl D-Norleucinate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.