Description

3-Triisopropylsiloxy-2,3,3A,7A-Tetrahydrobenzo(B)Thiophen-5(4H)-One 1,1-Dioxide is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfone and silyl-protected hydroxyl functional groups. This compound is critical for its role in the synthesis of complex, biologically active molecules, offering precise control over stereochemistry and reactivity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potential drug candidates, especially those containing complex heterocyclic scaffolds.
• Medicinal Chemistry Research: Used in exploratory synthesis for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Synthesis of Sulfone-Containing Compounds: Utilized to introduce the sulfone moiety, which is a privileged structure in many bioactive molecules and agrochemicals.
• Chiral Synthesis: The protected chiral center makes it valuable for the asymmetric synthesis of enantiomerically pure compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of proprietary compounds for clients.

Basic Information

Item	Details
Product Name	3-Triisopropylsiloxy-2,3,3A,7A-Tetrahydrobenzo(B)Thiophen-5(4H)-One 1,1-Dioxide
CAS No.	127486-98-0
Molecular Formula	C17H30O4SSi
Molecular Weight	358.57 g/mol
Synonyms	3-[(Triisopropylsilyl)oxy]-2,3,3a,7a-tetrahydro-1-benzothiophene-5(4H)-one 1,1-dioxide; 3-Triisopropylsiloxy-2,3,3a,7a-tetrahydrobenzo[b]thiophen-5(4H)-one 1,1-dioxide; 3-TIPS-Oxy-tetrahydrobenzothiophene sulfone; 3-Triisopropylsilyloxy perhydrobenzothiophene-5-one S,S-dioxide
EINECS	Contact for details

Quality Control

Our 3-Triisopropylsiloxy-2,3,3A,7A-Tetrahydrobenzo(B)Thiophen-5(4H)-One 1,1-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.